The Dihydrouridine landscape from tRNA to mRNA: a perspective on synthesis, structural impact and function
The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases Radiators and is typically found within the eponym D-loop of tRNAs.Despite its apparent simplicity, D is structurally unique, with the potential to deeply affect the RNA backbone and many, if not all, RNA-conne